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Common Side Effects

TV·2025–present·1 season, 10 episodes·Adult Swim·Animation, Drama, Comedy·23m·8.4·Created by Joseph Bennett, Steve Hely

Streaming on (US) HBO Max Amazon ChannelYouTube TVAdult SwimSee all

Former high school lab partners Marshall and Frances begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.

Highest-rated episodes all ranked

  1. 01Common Side Effects S01E03HildyS01E03 · 7.9Marshall visits an old mentor as new pressures mount.
  2. 02Common Side Effects S01E10RaidS01E10 · 7.9Dangerous forces converge on Marshall's camp.
  3. 03Common Side Effects S01E01PilotS01E01 · 7.7Marshall meets his old high school classmate Frances and lets her in on a world-changing secret.

Cast

Dave KingDave KingMarshall Cuso (voice)Emily PendergastEmily PendergastFrances Applewhite (voice)Mike JudgeMike JudgeRick Kruger (voice)Martha KellyMartha KellyAgent Harrington (voice)Joseph Lee AndersonJoseph Lee AndersonAgent Copano (voice)

Episodes by season

Season01Episode ratings across the season — the gold bar is its best episode10Episodes2025Aired 7.5Season avg
  1. S01E01Common Side Effects S01E01PilotFebruary 2, 2025 7.7Marshall meets his old high school classmate Frances and lets her in on a world-changing secret.
  2. S01E02Common Side Effects S01E02Lakeshore LimitedFebruary 2, 2025 7.5Marshall's forced on the run as the DEA pursues him.
  3. S01E03Common Side Effects S01E03Season's bestHildyFebruary 9, 2025 7.9Marshall visits an old mentor as new pressures mount.
  4. S01E04Common Side Effects S01E04DumpsiteFebruary 16, 2025 7.6Frances tracks down Marshall in an unlikely location.
  5. S01E05Common Side Effects S01E05Star-Tel-LiteFebruary 23, 2025 7.1Marshall, Frances, and their crazy neighbors deal with the aftermath of a dangerous incident.
  6. S01E06Common Side Effects S01E06In the SystemMarch 2, 2025 7.5Stuck in jail, Marshall faces new threats.
  7. S01E07Common Side Effects S01E07BlowfishMarch 9, 2025 7.4A chance encounter offers a risky opportunity for escape.
  8. S01E08Common Side Effects S01E08Amelia & WyattMarch 16, 2025 7.2Marshall and his new ally make a bold move.
  9. S01E09Common Side Effects S01E09Cliff's EdgeMarch 23, 2025 7.6Marshall's mushroom project grows out of hand.
  10. S01E10Common Side Effects S01E10RaidMarch 30, 2025 7.9Dangerous forces converge on Marshall's camp.

Season 1 ranked & reviewed

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