The essential episodes of My Friend's Little Sister Has It In for Me!

Watch these 12 in order and you've got My Friend's Little Sister Has It In for Me! — each pick states its reason.

1. 01

   S01E01 · Pilot · October 4, 2025 · 24m

   My Friend's Little Sister Has It In for Me9.0

   Akiteru just wants to work toward his future, but his friend's little sister won't allow him any peace.

2. 02

   S01E02 · Top rated · October 11, 2025 · 24m

   The Cousin I Haven't Seen in Years Is Cold to Me9.0

   Now that Mashiro has moved to his school, can Akiteru manage to make her open up to him?

3. 03

   S01E03 · Season 1 peak · October 18, 2025 · 24m

   Only I Can Be a Pain to My Uncle’s Daughter10.0

   Akiteru decides to throw a welcome party for Mashiro, but first he must convince her to attend.

4. 04

   S01E04 · Top rated · October 25, 2025 · 24m

   My Friend's Little Sister Might Be a Delinquent10.0

   Akiteru and Iroha recall how they first met.

5. 05

   S01E05 · Top rated · November 1, 2025 · 24m

   My Friend's Little Sister Keeps Getting Close to Me9.0

   A look back at how Iroha came to be the voice actress for 05th Floor Alliance.

6. 06

   S01E06 · Top rated · November 8, 2025 · 24m

   My Friend's Little Sister Has It In for My Friend's Enemy10.0

   While at the mall with Mashiro and Iroha, Akiteru learns why Mashiro left her old school.

7. 07

   S01E07 · Top rated · November 15, 2025 · 24m

   The Girl Who Confessed to Me Is Cold to Me in Reality10.0

   Akiteru tries to give a proper reply to Mashiro's love confession, but she's brutally cold to him in person.

8. 08

   S01E08 · Top rated · November 22, 2025 · 24m

   Everyone I Know Is Being Weird With Me10.0

   Sumire asks Akiteru for help with a problem that could endanger her future with 05th Floor Alliance.

9. 09

   S01E09 · Top rated · November 29, 2025 · 24m

   My Fake Girlfriend Gets Tough When I Respond To Her Confession10.0

   Akiteru and Iroha head to Otoi's studio to record for the game, but Iroha has ideas of her own.

10. 10

    S01E10 · Top rated · December 6, 2025 · 24m

    My Friend's Little Sister Only Gets an Apology from Me10.0

    Akiteru must clear the air with Iroha to keep 05th Floor Alliance running smoothly.

11. 11

    S01E11 · Top rated · December 13, 2025 · 24m

    We're Perfect for Training the Drama Club10.0

    With 05th Floor Alliance's help, the drama club is ready for the big competition... but then disaster strikes.

12. 12

    S01E12 · Series finale · December 20, 2025 · 24m

    My Friend's Little Sister Really Does Have It In for Me10.0

    Can Akiteru save the drama club and secure 05th Floor Alliance's future?